{"id":1454,"date":"2022-04-12T19:16:06","date_gmt":"2022-04-12T19:16:06","guid":{"rendered":"https:\/\/corakid.com\/?page_id=1454"},"modified":"2025-05-23T09:01:53","modified_gmt":"2025-05-23T09:01:53","slug":"artificial-kidney-induced-kidney-injury-akiki-2","status":"publish","type":"page","link":"https:\/\/corakid.com\/en\/research\/theme-2\/artificial-kidney-induced-kidney-injury-akiki-2\/","title":{"rendered":"Artificial Kidney-Induced Kidney Injury (AKIKI)"},"content":{"rendered":"
Projects<\/h5>\n\n\n

Renal replacement therapy (RRT) is used for severe acute kidney injury (AKI). We published the first large trial on RRT timing (AKIKI). It showed no difference in mortality between 2 initiation strategies (early vs delayed) but the delayed one (allowing some patients to escape RRT) was associated with faster renal recovery. RRT might constitute a second hit, which would impair renal recovery by: 1\/modifying renal hemodynamic; 2\/activating platelets and neutrophils through contact with dialysis membrane; 3\/removing plasma molecules involved in tubules regeneration (e.g. vit B3). To test these hypotheses, we set up a rat model of RRT after AKI. Kidney histology and function, tubular damage, hemodynamic, platelets\/neutrophils activation\/aggregation and NAD+ metabolites will be assessed. It will then be tested in blood\/urine samples from patients included in AKIKI2 trial. We will also assess if plasma concentration of NAD+ metabolites is correlated with the time between AKI and recovery.<\/p>\n\n\n

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Publications<\/h5>\n
    \n
  1. Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial. Gaudry S, Hajage D, \u2026. and Dreyfuss D. Lancet<\/i><\/b>. 2021. 397(10281):1293-1300. doi: 10.1016\/S0140-6736(21)00350-0<\/li>\n
  2. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. STARRT-AKI Investigators, \u2026, Gaudry S\u2026 and Zarbock A. N <\/i><\/b>Engl<\/i><\/b> J Med <\/i><\/b>2020. 383(3):240-251. doi: 10.1056\/NEJMoa2000741.<\/li>\n
  3. Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients. Gaudry S, Quenot JP\u2026and Dreyfuss D. Am J Respir <\/i><\/b>Crit<\/i><\/b> Care Med <\/i><\/b>2019. 99(9):1066-1075. doi: 10.1164\/rccm.201810-1906CP.<\/li>\n
  4. Timing of Renal Support and Outcome of Septic Shock and Acute Respiratory Distress Syndrome. A Post Hoc Analysis of the AKIKI Randomized Clinical Trial. Gaudry S, Hajage D, \u2026. and Dreyfuss D. Am J Respir <\/i><\/b>Crit<\/i><\/b> Care Med <\/i><\/b>2018. 198(1):58-66. doi:10.1164\/rccm.201706-1255OC.<\/li>\n
  5. Initiation of Renal-Replacement Therapy in the Intensive Care Unit. Gaudry S, Hajage D and Dreyfuss D. N <\/i><\/b>Engl<\/i><\/b> J Med <\/i><\/b>2016;375:122\u2013133. doi: 10.1056\/NEJMc1610500.<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"

    Projets L\u2019\u00e9puration extra-r\u00e9nale (EER) est utilis\u00e9e en cas d\u2019insuffisance r\u00e9nale aigue\u0308 (IRA) s\u00e9v\u00e8re. Nous avons publie\u0301 un essai sur le timing de l\u2019EER ne montrant pas de diff\u00e9rence de mortalit\u00e9 entre 2 strat\u00e9gies d’initiation (pr\u00e9coce ou diff\u00e9r\u00e9e). La strat\u00e9gie diff\u00e9r\u00e9e (conduisant a\u0300 moins d\u2019EER) \u00e9tait associ\u00e9e a\u0300 une r\u00e9cup\u00e9ration r\u00e9nale plus rapide. L\u2019EER pourrait alt\u00e9rer […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_cbd_carousel_blocks":"[]","footnotes":""},"class_list":["post-1454","page","type-page","status-publish","hentry"],"yoast_head":"\nArtificial Kidney-Induced Kidney Injury (AKIKI) - CoRaKiD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/corakid.com\/en\/research\/theme-2\/artificial-kidney-induced-kidney-injury-akiki-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Artificial Kidney-Induced Kidney Injury (AKIKI) - CoRaKiD\" \/>\n<meta property=\"og:description\" content=\"Projets L\u2019\u00e9puration extra-r\u00e9nale (EER) est utilis\u00e9e en cas d\u2019insuffisance r\u00e9nale aigue\u0308 (IRA) s\u00e9v\u00e8re. Nous avons publie\u0301 un essai sur le timing de l\u2019EER ne montrant pas de diff\u00e9rence de mortalit\u00e9 entre 2 strat\u00e9gies d’initiation (pr\u00e9coce ou diff\u00e9r\u00e9e). La strat\u00e9gie diff\u00e9r\u00e9e (conduisant a\u0300 moins d\u2019EER) \u00e9tait associ\u00e9e a\u0300 une r\u00e9cup\u00e9ration r\u00e9nale plus rapide. 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Nous avons publie\u0301 un essai sur le timing de l\u2019EER ne montrant pas de diff\u00e9rence de mortalit\u00e9 entre 2 strat\u00e9gies d’initiation (pr\u00e9coce ou diff\u00e9r\u00e9e). La strat\u00e9gie diff\u00e9r\u00e9e (conduisant a\u0300 moins d\u2019EER) \u00e9tait associ\u00e9e a\u0300 une r\u00e9cup\u00e9ration r\u00e9nale plus rapide. 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