{"id":15,"date":"2019-09-09T10:01:06","date_gmt":"2019-09-09T10:01:06","guid":{"rendered":"http:\/\/corakid.com\/?page_id=15"},"modified":"2025-05-23T09:08:22","modified_gmt":"2025-05-23T09:08:22","slug":"theme-4","status":"publish","type":"page","link":"https:\/\/corakid.com\/en\/research\/theme-4\/","title":{"rendered":"Group 4 : Targets and strategies for diagnosis and therapy of chronic kidney disease"},"content":{"rendered":"<h2>Groupe 4 : Cibles et Strat\u00e9gies pour Diagnostique et Th\u00e9rapie<\/h2>\n<h5>Vue d&rsquo;ensemble<\/h5>\n\n\n<p class=\"has-very-light-gray-background-color has-background wp-block-paragraph\"><p>Even though many aspects of the complex mechanisms orchestrating progression of renal disease have been identified, so far there is no specific treatment to slow down or prevent CKD progression. Therefore, identifying novel specific therapeutic targets and proposing more effective treatments against the progression of CKD is one of the major challenges of public health today. In the previous years, we were successful in identifying several new mediators of renal diseases having the potential to be targets for therapy. We will pursue this objective by investigating additional pathways of therapy: some, like Cx43, CB1 receptor and Sema3C, require inhibition because of their detrimental pro-inflammatory and pro-fibrotic action, whereas other, like Epac1 and podo \u03b3C, need activation because of their protective action. In addition, we are strengthening our approach by proposing innovative strategies that allow either a more efficient diagnosis or a targeted tissue-specific drug delivery.<\/p>\n<p>Cette th\u00e9matique de recherche est compos\u00e9e de 4 groupes :<\/p><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Mediators of renal disease and cardiorenal type II syndrome<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Group Leader <\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Christos E Chadjichristos<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">(CRCN Inserm)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Members :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jean-Jacques Boffa (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">David Buob (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">J Ni (Visiting Professor)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Emmanuel Esteve (MD, post-doc)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Louis Boutin (MD, PhD Student)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Elena Roger (PhD Student)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Safia Hadjadj (Research Engineer)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M Julien (M2 Student)<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Targets of glomerular disease<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Group Leaders :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Christos Chatziantoniou<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">(DR1 Inserm)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;Am\u00e9lie Calmont (PhD, Post-doc)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Members :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jean-Claude Dussaule (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">David Buob (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lilia Abbad (PhD, post-doc)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rym Chalghoumi (PhD Student)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y&nbsp; Shen (PhD Student)<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Cannabinoid receptors and renal fibrosis<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Group Leader :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">H\u00e9l\u00e8ne Fran\u00e7ois (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Members :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Isabelle Brocheriou (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Marianne Wang (Research Engineer)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L Abbadi (M2 student)<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Mediators of glomerulomephritis<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Group Leader :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Khalil El-Karoui (PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Members :<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">David Buob (PU-PH)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lisa M\u00e9lis (PhD Student)<\/p>","protected":false},"excerpt":{"rendered":"<p>Groupe 4 : Cibles et Strat\u00e9gies pour Diagnostique et Th\u00e9rapie Vue d&rsquo;ensemble M\u00eame si de nombreux aspects des m\u00e9canismes complexes orchestrant la progression de la maladie r\u00e9nale ont \u00e9t\u00e9 identifi\u00e9s, il n&rsquo;existe jusqu&rsquo;\u00e0 pr\u00e9sent aucun traitement sp\u00e9cifique pour ralentir ou emp\u00eacher la progression de la MRC. Par cons\u00e9quent, identifier de nouvelles cibles th\u00e9rapeutiques sp\u00e9cifiques et [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":25,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_cbd_carousel_blocks":"[]","footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Groupe 4 : Cibles et strat\u00e9gies pour le diagnostique et la th\u00e9rapie de la maladie r\u00e9nale chronique - CoRaKiD<\/title>\n<meta name=\"description\" content=\"Cibles et Strat\u00e9gies pour Diagnostique et Th\u00e9rapie\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/corakid.com\/en\/research\/theme-4\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Groupe 4 : Cibles et strat\u00e9gies pour le diagnostique et la th\u00e9rapie de la maladie r\u00e9nale chronique - 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