{"id":2262,"date":"2025-05-22T14:07:36","date_gmt":"2025-05-22T14:07:36","guid":{"rendered":"https:\/\/corakid.com\/?page_id=2262"},"modified":"2026-02-24T14:42:52","modified_gmt":"2026-02-24T14:42:52","slug":"equipe-2-traiter-les-maladies-renales-physiopathologie-et-cibles-therapeutiques","status":"publish","type":"page","link":"https:\/\/corakid.com\/en\/equipe-2-traiter-les-maladies-renales-physiopathologie-et-cibles-therapeutiques\/","title":{"rendered":"\u00c9quipe 2 – Traiter les maladies R\u00e9nales : Physiopathologie et Cibles th\u00e9rapeutiques"},"content":{"rendered":"

L\u2019\u00c9quipe 2 se concentre sur la maladie r\u00e9nale chronique (MRC), en poursuivant ses efforts pour identifier de nouveaux m\u00e9diateurs de la maladie pouvant servir de cibles th\u00e9rapeutiques. Le projet repose sur deux axes principaux : approfondir la compr\u00e9hension des m\u00e9canismes pathophysiologiques de la MRC, et d\u00e9velopper de nouvelles approches th\u00e9rapeutiques et outils de suivi des patients. Cette strat\u00e9gie s\u2019accompagne du d\u00e9veloppement de nouvelles m\u00e9thodes diagnostiques et th\u00e9rapeutiques, dans une d\u00e9marche collaborative avec l\u2019ensemble de l\u2019unit\u00e9.<\/p>\n\n\n\n

\n
\n

Avanc\u00e9es dans la physiopathologie de la maladie r\u00e9nale chronique<\/strong><\/h4>\n\n\n\n

Nous avons identifi\u00e9 plusieurs prot\u00e9ines fortement impliqu\u00e9es dans la progression de la MRC. Selon l\u2019agression initiale, ces prot\u00e9ines sont exprim\u00e9es de novo ou surexprim\u00e9es dans diff\u00e9rents compartiments r\u00e9naux, favorisant l\u2019inflammation et la fibrose tissulaire.
Nous continuons \u00e0 identifier et proposer de nouveaux m\u00e9diateurs comme cibles th\u00e9rapeutiques.<\/p>\n\n\n\n

R\u00e9cepteur cannabino\u00efde 1 et MRC<\/p>\n\n\n\n

Implication de la lectine Gal-3 dans le syndrome cardio-r\u00e9nal<\/p>\n\n\n\n

R\u00f4le des jonctions intracellulaires dans la progression de la maladie r\u00e9nale<\/p>\n\n\n\n

R\u00f4le de MMP9 dans la ciliog\u00e9n\u00e8se et la n\u00e9phronophtise<\/p>\n\n\n\n

Implication des prot\u00e9ines de choc thermique dans les glom\u00e9rulopathies<\/p>\n\n\n\n

Isthmin-1 : un nouveau m\u00e9diateur de la maladie r\u00e9nale chronique<\/p>\n\n\n\n

Maladies hyperinflammatoires associ\u00e9es \u00e0 l\u2019amylose inflammatoire<\/p>\n<\/div>\n\n\n\n

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Approches th\u00e9rapeutiques et biomarqueurs pour le suivi des patients<\/strong><\/h4>\n\n\n\n

Afin de mieux comprendre la progression de la MRC, nous renforcerons notre approche en proposant de nouvelles m\u00e9thodologies et techniques permettant soit un diagnostic plus efficace des alt\u00e9rations structurelles, soit une administration cibl\u00e9e de traitements. Nous d\u00e9veloppons \u00e9galement de nouveaux dispositifs in vitro pour tester le potentiel des prot\u00e9ines identifi\u00e9es en tant que cibles th\u00e9rapeutiques.<\/p>\n\n\n\n

Carabin : une protection contre la toxicit\u00e9 de la calcineurine<\/p>\n\n\n\n

Glom\u00e9rule sur puce<\/p>\n\n\n\n

Dysfonction podocytaire et glom\u00e9ruloscl\u00e9rose segmentaire et focale (FSGS)<\/p>\n\n\n\n

Maladies glom\u00e9rulaires rares<\/p>\n\n\n\n

Inhibiteurs du complexe d\u2019attaque membranaire (MAC)<\/p>\n<\/div>\n<\/div>\n\n\n\n

Membres de l’\u00e9quipe<\/strong><\/h3>\n\n\n\n
\n
\"Christos
Christos CHADJICHRISTOS
Chef d’\u00e9quipe – DR Inserm<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
Khalil EL-KAROUI
PU-PH<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
H\u00e9l\u00e8ne FRANCOIS
PU-PH<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
Christos CHATZIANTONIOU
Directeur de Corakid – DR Inserm<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
R\u00e9mi PIEDAGNEL
CR Inserm<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
Sophie GEORGIN-LAVIALLE
PU-PH<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"
Jean-Jacques BOFFA
PU-PH<\/strong><\/figcaption><\/figure>\n<\/figure>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

L\u2019\u00c9quipe 2 se concentre sur la maladie r\u00e9nale chronique (MRC), en poursuivant ses efforts pour identifier de nouveaux m\u00e9diateurs de la maladie pouvant servir de cibles th\u00e9rapeutiques. Le projet repose sur deux axes principaux : approfondir la compr\u00e9hension des m\u00e9canismes pathophysiologiques de la MRC, et d\u00e9velopper de nouvelles approches th\u00e9rapeutiques et outils de suivi des […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"modele-corakid","meta":{"_cbd_carousel_blocks":"[]","footnotes":""},"class_list":["post-2262","page","type-page","status-publish","hentry"],"yoast_head":"\n\u00c9quipe 2 - Traiter les maladies R\u00e9nales : Physiopathologie et Cibles th\u00e9rapeutiques - CoRaKiD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/corakid.com\/en\/equipe-2-traiter-les-maladies-renales-physiopathologie-et-cibles-therapeutiques\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9quipe 2 - Traiter les maladies R\u00e9nales : Physiopathologie et Cibles th\u00e9rapeutiques - CoRaKiD\" \/>\n<meta property=\"og:description\" content=\"L\u2019\u00c9quipe 2 se concentre sur la maladie r\u00e9nale chronique (MRC), en poursuivant ses efforts pour identifier de nouveaux m\u00e9diateurs de la maladie pouvant servir de cibles th\u00e9rapeutiques. 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