{"id":73,"date":"2019-09-10T09:47:46","date_gmt":"2019-09-10T09:47:46","guid":{"rendered":"http:\/\/corakid.com\/?page_id=73"},"modified":"2025-06-05T09:18:46","modified_gmt":"2025-06-05T09:18:46","slug":"unit-presentation","status":"publish","type":"page","link":"https:\/\/corakid.com\/en\/unit-presentation\/","title":{"rendered":"L\u2019UNIT\u00c9"},"content":{"rendered":"

Contexte international<\/strong><\/h4>\n\n\n\n

L\u2019objectif de notre unit\u00e9 est de lutter contre les maladies r\u00e9nales, un enjeu majeur de sant\u00e9 publique. Le nombre de personnes souffrant de dysfonction(s) r\u00e9nale(s) est estim\u00e9 \u00e0 1 milliard dans le monde d\u2019ici 2025, avec un taux d\u2019augmentation annuel de 7 \u00e0 9 % depuis 2000. Le d\u00e9clin progressif de la fonction r\u00e9nale conduit \u00e0 une insuffisance r\u00e9nale terminale (IRT), pour laquelle les seules solutions actuellement disponibles sont l\u2019h\u00e9modialyse ou la transplantation, avec une esp\u00e9rance de vie m\u00e9diane de 5 \u00e0 7 ans. Ainsi, l\u2019objectif principal de notre unit\u00e9 est de proposer une approche globale des m\u00e9canismes responsables de la perte de fonction r\u00e9nale et de la r\u00e9paration tissulaire alt\u00e9r\u00e9e, d\u2019identifier des biomarqueurs sp\u00e9cifiques pour un diagnostic pr\u00e9coce, et de d\u00e9velopper des traitements plus efficaces et cibl\u00e9s contre l\u2019insuffisance r\u00e9nale progressive afin d\u2019enrayer l\u2019augmentation du nombre de personnes n\u00e9cessitant une dialyse et\/ou une transplantation.<\/p>\n\n\n\n

Strat\u00e9gie de Recherche<\/strong><\/h4>\n\n\n\n

Notre strat\u00e9gie de recherche repose sur l\u2019utilisation de m\u00e9thodologies de pointe telles que des souris g\u00e9n\u00e9tiquement modifi\u00e9es, la d\u00e9livrance cibl\u00e9e de m\u00e9dicaments sp\u00e9cifiques, ainsi que des analyses bio-informatiques et g\u00e9n\u00e9tiques. Ces approches permettent d\u2019\u00e9tudier le r\u00f4le d\u2019un g\u00e8ne candidat pr\u00e9d\u00e9fini, et\/ou d\u2019appliquer des hypoth\u00e8ses th\u00e9rapeutiques pour identifier les m\u00e9canismes et m\u00e9diateurs sous-jacents, et\/ou de corr\u00e9ler certaines mutations g\u00e9n\u00e9tiques \u00e0 des pathologies r\u00e9nales sp\u00e9cifiques.Un objectif commun aux diff\u00e9rents projets est l\u2019identification de processus cellulaires alt\u00e9r\u00e9s, de nouveaux marqueurs ou d\u2019associations g\u00e9n\u00e9tiques pr\u00e9dictives d\u2019un risque accru de maladie r\u00e9nale, et la validation de cibles th\u00e9rapeutiques exploitables dans les pathologies r\u00e9nales.<\/p>\n\n\n\n

Organisation de l’unit\u00e9<\/strong><\/h4>\n\n\n\n

L\u2019unit\u00e9 CoRaKiD est dirig\u00e9e par le Dr Christos Chatziantoniou et, depuis le 1er janvier 2024, \u00e9galement par le Dr Juliette Hadchouel. Les projets sont r\u00e9partis en 4 th\u00e9matiques, comme illustr\u00e9 dans le sch\u00e9ma ci-dessous. \u00c0 partir de janvier 2025, nous pr\u00e9voyons de structurer l\u2019unit\u00e9 en deux \u00e9quipes, dirig\u00e9es respectivement par le Pr Emmanuel Letavernier (\u00c9quipe 1) et le Dr Christos Chadjichristos. L\u2019\u00c9quipe 1 se concentrera sur la pr\u00e9vention de la progression vers la maladie r\u00e9nale chronique (MRC), tandis que l\u2019\u00c9quipe 2 sera d\u00e9di\u00e9e au traitement de la MRC.<\/p>\n\n\n\n

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Contexte international L\u2019objectif de notre unit\u00e9 est de lutter contre les maladies r\u00e9nales, un enjeu majeur de sant\u00e9 publique. Le nombre de personnes souffrant de dysfonction(s) r\u00e9nale(s) est estim\u00e9 \u00e0 1 milliard dans le monde d\u2019ici 2025, avec un taux d\u2019augmentation annuel de 7 \u00e0 9 % depuis 2000. Le d\u00e9clin progressif de la fonction […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"modele-corakid","meta":{"_cbd_carousel_blocks":"[]","footnotes":""},"class_list":["post-73","page","type-page","status-publish","hentry"],"yoast_head":"\nL\u2019UNIT\u00c9 - CoRaKiD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/corakid.com\/en\/unit-presentation\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019UNIT\u00c9 - CoRaKiD\" \/>\n<meta property=\"og:description\" content=\"Contexte international L\u2019objectif de notre unit\u00e9 est de lutter contre les maladies r\u00e9nales, un enjeu majeur de sant\u00e9 publique. 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