{"id":78,"date":"2019-09-10T14:11:21","date_gmt":"2019-09-10T14:11:21","guid":{"rendered":"http:\/\/corakid.com\/?page_id=78"},"modified":"2025-05-23T08:50:03","modified_gmt":"2025-05-23T08:50:03","slug":"history","status":"publish","type":"page","link":"https:\/\/corakid.com\/en\/unit-presentation\/history\/","title":{"rendered":"History"},"content":{"rendered":"
\"\"<\/figure>\n\n\n\n

La naissance de notre centre de recherche est l\u2019oeuvre de Gabriel Richet<\/a>, un des fondateurs de la N\u00e9phrologie moderne. En 1960, Gabriel Richet quitte Jean Hamburger et l\u2019h\u00f4pital Necker pour l\u2019h\u00f4pital Tenon, o\u00f9 avec Raymond Ardaillou<\/a> et Claude Amiel<\/a>, ses deux premiers assistants, il fonde une grande \u00e9cole de N\u00e9phrologie compos\u00e9e de deux Services de N\u00e9phrologie, un service d\u2019Explorations Fonctionnelles et \u00e0 partir de 1964 une Unit\u00e9 Inserm, U64 \u00ab N\u00e9phrologie normale et pathologique \u00bb.<\/p>\n\n\n\n

Gabriel Richet va se consacrer \u00e0 la recherche en physiopathologie r\u00e9nale et, avec ses collaborateurs, il identifie, par leurs caract\u00e9ristiques histologiques et la mise en \u00e9vidence de prot\u00e9ines sp\u00e9cifiques par immunofluorescence, de nombreuses n\u00e9phropathies glom\u00e9rulaires. Il d\u00e9couvre les cellules claires et sombres du tube distal du n\u00e9phron, appel\u00e9es ensuite principales et intercalaires, et d\u00e9montre que les secondes jouent un r\u00f4le essentiel dans l\u2019excr\u00e9tion des protons. Il \u00e9tudie \u00e9galement la prot\u00e9ine de Tamm Horsfall ou uromoduline et son excr\u00e9tion \u00e0 partir de l\u2019anse de Henle. Il consacrera \u00e9galement de nombreux travaux \u00e0 l\u2019excr\u00e9tion urinaire d\u2019acide urique, de calcium et au d\u00e9membrement des glom\u00e9rulopathies primitives (maladies qui touchent les glom\u00e9rules r\u00e9naux).<\/p>\n\n\n\n

Raymond Ardaillou succ\u00e8de \u00e0 Gabriel Richet et dirige l\u2019U64 entre 1985-1997. Ses recherches sur la physiologie et la physiopathologie du glom\u00e9rule r\u00e9nal seront pionni\u00e8res. On consid\u00e9rait jusqu\u2019alors que le glom\u00e9rule se comportait comme un filtre passif. Avec ses collaborateurs, Raymond Ardaillou apporte la preuve que le glom\u00e9rule est un syst\u00e8me tr\u00e8s complexe, avec des cellules de type et de fonctions diff\u00e9rents ob\u00e9issant \u00e0 un contr\u00f4le hormonal, et qu\u2019il est \u00e9galement le lieu de synth\u00e8se de mol\u00e9cules particuli\u00e8res. Entre autres, son \u00e9quipe est la premi\u00e8re \u00e0 d\u00e9montrer l\u2019existence des r\u00e9cepteurs de l\u2019angiotensine dans les glom\u00e9rules et \u00e0 \u00e9tudier leur r\u00f4le.<\/p>\n\n\n\n

Raymond Ardaillou s\u2019int\u00e9resse ensuite aux facteurs vasoactifs et au r\u00f4le de l\u2019apport alimentaire en sel dans le d\u00e9veloppement de la pression art\u00e9rielle. Avec ses collaborateurs, il met en \u00e9vidence le r\u00f4le majeur profibrosant de l\u2019angiotensine II et de l\u2019endoth\u00e9line, ind\u00e9pendamment de leurs effets sur la pression art\u00e9rielle. Il montre que l\u2019augmentation au long terme de la teneur en sel du r\u00e9gime chez les chimpanz\u00e9s accroit de fa\u00e7on durable la pression art\u00e9rielle de ces animaux.<\/p>\n\n\n\n

Pierre Ronco<\/a> succ\u00e8de \u00e0 Raymond Ardaillou en 1998. Pendant son mandat, l\u2019Unit\u00e9 \u00e9volue aussi bien au niveau th\u00e9matique qu\u2019 administratif: d\u2019abord Inserm U 489 \u00ab Remodelage et fibrogen\u00e8se du tissu r\u00e9nal \u00bb (1998-2004), puis unit\u00e9 mixte de recherche Inserm 702\/universit\u00e9 Pierre et Marie-Curie \u00ab Remodelage et r\u00e9paration du tissu r\u00e9nal \u00bb, (2005-2013), et actuellement UMR S 1155 \u00ab Des maladies r\u00e9nales aux maladies fr\u00e9quentes, remodelage et r\u00e9paration \u00bb (2014-2018).<\/p>","protected":false},"excerpt":{"rendered":"

La naissance de notre centre de recherche est l\u2019oeuvre de Gabriel Richet, un des fondateurs de la N\u00e9phrologie moderne. En 1960, Gabriel Richet quitte Jean Hamburger et l\u2019h\u00f4pital Necker pour l\u2019h\u00f4pital Tenon, o\u00f9 avec Raymond Ardaillou et Claude Amiel, ses deux premiers assistants, il fonde une grande \u00e9cole de N\u00e9phrologie compos\u00e9e de deux Services de N\u00e9phrologie, un service d\u2019Explorations […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":73,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"modele-corakid","meta":{"_cbd_carousel_blocks":"[]","footnotes":""},"class_list":["post-78","page","type-page","status-publish","hentry"],"yoast_head":"\nHistoire - CoRaKiD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/corakid.com\/en\/unit-presentation\/history\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histoire - CoRaKiD\" \/>\n<meta property=\"og:description\" content=\"La naissance de notre centre de recherche est l\u2019oeuvre de Gabriel Richet, un des fondateurs de la N\u00e9phrologie moderne. En 1960, Gabriel Richet quitte Jean Hamburger et l\u2019h\u00f4pital Necker pour l\u2019h\u00f4pital Tenon, o\u00f9 avec Raymond Ardaillou et Claude Amiel, ses deux premiers assistants, il fonde une grande \u00e9cole de N\u00e9phrologie compos\u00e9e de deux Services de N\u00e9phrologie, un service d\u2019Explorations […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/corakid.com\/en\/unit-presentation\/history\/\" \/>\n<meta property=\"og:site_name\" content=\"CoRaKiD\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-23T08:50:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/corakid.com\/wp-content\/uploads\/2019\/10\/frise2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1590\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/\",\"url\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/\",\"name\":\"Histoire - CoRaKiD\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/#primaryimage\"},\"thumbnailUrl\":\"http:\\\/\\\/corakid.com\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/frise2-1024x773.jpg\",\"datePublished\":\"2019-09-10T14:11:21+00:00\",\"dateModified\":\"2025-05-23T08:50:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/#primaryimage\",\"url\":\"http:\\\/\\\/corakid.com\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/frise2-1024x773.jpg\",\"contentUrl\":\"http:\\\/\\\/corakid.com\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/frise2-1024x773.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/history\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/corakid.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"L\u2019UNIT\u00c9\",\"item\":\"https:\\\/\\\/corakid.com\\\/unit-presentation\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Histoire\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/corakid.com\\\/en\\\/\",\"name\":\"CoRaKiD\",\"description\":\"UMRS 1155 Common and Rare Kidney Diseases\",\"publisher\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/corakid.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#organization\",\"name\":\"CoRaKiD\",\"url\":\"https:\\\/\\\/corakid.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/corakid.com\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/logo5.png\",\"contentUrl\":\"https:\\\/\\\/corakid.com\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/logo5.png\",\"width\":652,\"height\":247,\"caption\":\"CoRaKiD\"},\"image\":{\"@id\":\"https:\\\/\\\/corakid.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Histoire - CoRaKiD","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/corakid.com\/en\/unit-presentation\/history\/","og_locale":"en_GB","og_type":"article","og_title":"Histoire - CoRaKiD","og_description":"La naissance de notre centre de recherche est l\u2019oeuvre de Gabriel Richet, un des fondateurs de la N\u00e9phrologie moderne. 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